Adrenals gland

Adrenals

Each adrenal has two parts, an outer cortex and inner medulla.

Location: Over the superior end of kidneys.

 Adrenal Cortex. The outer part of adrenals which further consists of three zones

(i) Zona glomerulosa:

Hormones: Mineralocorticoids (mainly aldosterone)
Functions: Regulation of Na+ and K+ in blood. Increases Na+ level, and lowers
that of K+

(ii) Zona Fasciculata

Hormone: Glucocorticoids (Mainly cortisol)
Function: Increase glucose level in body by changing proteins and fast to
carbohydrates.
Hypersecretion: Cushing’s syndrome due to high glucose level, and high Na+
level caused by excess of glucocorticoids. High B.P. and rise in blood volume.

(iii) Zona reticulosa

Hormone: Androgens (Male sex hormones)
Function: Development of male secondary sexual characters.
Hypersecretion: Adrenal virilism due to excess of androgens secreted in female
who develops certain masculine features.

(b) Adrenal medulla (The inner portion of adrenals)
The adrenals are commonly called the glands of emergency because of the role of
their hormones.

Hormone:

(i) Noradrenaline (= Norepinephrine) Secreted under normal conditions.

Function: Regulate blood pressure under normal condition by constricting small
arteries.

(ii) Adrenaline (= Epinephrine) secreted under conditions of physical and mental
stress such as grief, pain, injury, anger, fall in blood pressure and blood sugar,
cold fear, etc. In man, adrenalin is produced in much more amount than
nonadrenaline.

Function: Increase of heart beat rate, breathing rate and blood sugar. Dilation
of small arteries of heart, brain and skeletal muscles. Constriction of small
arteries of skin: constriction of small arteries of skin; contraction of spleen to
squeeze out the reserve, dilation of pupil, contraction of arrector pili muscles
(goose flesh condition).


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